Network / Labs
We strive to build a network of enthusiastic aging researchers in Switzerland.
Biozentrum, University of Basel
Research: Understanding the molecular mechanisms that control growth and metabolism in health and disease may reveal new therapeutic strategies for a wide variety of disorders.
Research interests: We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.
Keywords: TOR (Target of Rapamycin), human tumors, new therapeutic strategies.
Biozentrum, University of Basel
Lab website: https://www.biozentrum.unibas.ch/handschin
Research: Skeletal muscle plasticity in health and disease.
Research interests: Our group is interested in the molecular mechanisms that underlie cell plasticity of skeletal muscle in health and disease, including adaptations to exercise, and the pathological changes in muscle atrophy, muscular dystrophies and aging.
Keywords: Skeletal muscle, exercise, transcriptional regulation, PGC-1alpha, muscular dystrophies.
Biozentrum, University of Basel
Research: Synapse development and neuromuscular disorders.
Research interests: Our goal is to understand the signaling pathways that contribute to the formation of synapses and that allow to restore them upon pathological alterations. We are particularly interested in the signals that trigger synaptic changes during learning processes, and in those important to maintain the neuromuscular synapses. In addition, it provides the basics for the better understanding of the loss of muscle mass and the associated impairment of mobility with age.
Keywords: Synapses, Neuromuscular disorders, and generalized muscle weakness.
Biozentrum, University of Basel
Research: The Zavolan group studies the role of (primarily) post-transcriptional regulation in cell fate determination.
Research interests: Computational/systems biology, miRNAs, mechanisms of aging, cell fate determination.
Keywords: miRNA, RNA-binding protein, computational methods, aging, cell fate determination.
Department of Rheumatology, Immunology and Allergology, University of Bern
Lab website: http://www.eggellab.com
Research: Immunologic plasticity in aging.
Research interests: Immunology, Aging, Type 2 Immunity, Immunoscenescence, Rejuvenation.
Institut für Zellbiologie, University of Bern
Lab website: www.towbinlab.org
Research: We study evolutionary tradeoffs between growth and aging.
Research interests: Optimality, Systems Biology, Aging, Growth.
Keywords: Genetics, quantitative Imaging, modeling
De Virgilio, Claudio
Department of Biology, University of Fribourg
Research: We try to understand the molecular mechanism that control entry into and exit from quiescence in the model organism Saccharomyces cerevisiae.
Research interests: We are interested in nutrient signalling pathways that control growth, quiescence and chronological ageing using physiological, biochemical, molecular and cell biological approaches.
Expertise: Target of rapamycin complex 1 (TORC1), Rag GTPases, amino acid signalling, Protein kinase A (PKA) signaling, chronological ageing.
Department of Biology, University of Fribourg
Lab website: https://www.unifr.ch/biology/research/flatt/
Research: Evolution of Aging and Longevity.
Research interests: Evolution and Mechanisms of Aging; Trade-Off between Lifespan and Reproduction; Antagonistic Pleiotropy; Endocrinology of Aging; Genetics and Genomics of Aging in Drosophila; Aging and Lifespan in Wild Populations.
Expertise: Evolutionary Biology; Population Genomics; Experimental Evolution; Genetic Analysis of Aging in Drosophila; Experimental Evolution of Aging; Endocrinology of Aging; Population Genetic Theory of Aging; Life History Theory
Department of Genetics and Evolution, University of Geneva
Research: How an adult animal (the freshwater cnidarian Hydra) can keep regenerating and forget about aging?
Research interests: Mechanisms that prevent aging, role of autophagy in the self-renewal of stock of adult stem cells, de novo neurogenesis, whole body regeneration
Expertise: Hydra model system, gene expression, gene silencing, cell cycle monitoring, autophagy sensor
Professor and Nestle Chair in Energy Metabolism
Laboratory of Integrative and Systems Physiology, EPFL
Lab website: http://auwerx-lab.epfl.ch/
Research interests: Our laboratory is using systems approaches to map the signalling networks that govern mitochondrial function and as such regulate organismal metabolism in health, aging and disease. We apply a state-of-the-art biological toolkit to study a variety of model systems, ranging from the plant Arabidopsis thaliana, over the nematode Caenorhabditis elegans and the mouse all the way to humans.
Expertise: Metabolic sensing, mitochondrial metabolism, nuclear receptor and cofactor biology, complex genetics, genetic reference populations, and aging.
Feige, Jerome N
Group Leader and Adjunct lecturer
Skeletal muscle & Aging Lab, Nestlé Institute of Heath Sciences
Lab website: https://www.nestleinstitutehealthsciences.com/scienceandtechnology/ageing/ageing-of-skeletal-muscle
Research interests: We study the molecular, cellular and nutritional mechanisms leading to the dysfunction of skeletal muscle during ageing, particularly the condition of sarcopenia, in which muscle mass and muscle function decline due to age. Sarcopenia involves multiple pathophysiological processes such as impaired neuro-muscular transition, altered excitation/contraction coupling, impaired regenerative capacity linked to stem cell exhaustion, defects of mitochondrial and energy metabolism in myofibers, and finally marbling of skeletal muscle with fat and fibrosis.
Our recent work has demonstrated that neuromuscular dysfunction is a major driver of sarcopenia (Pannerec et al, Aging 2016) and that remodeling of the extracellular matrix (ECM) during muscle regeneration is blunted in the aged muscle stem cell niche and can be targeted therapeutically (Lukjanenko et al., Nature Medicine 2016).
Expertise: Muscle biology, aging, exercise, molecular control of rodent physiology.
Preview your site across screen sizesKeywords: Aging in social insects.
Lab website: http://www.unil.ch/sgg
Research interests: Understanding the genetic basis of complex, common human diseases.
Lab website: http://lingner-lab.epfl.ch/
Research interests: Telomere structure and function.
Keywords: Genome stability, DNA replication, long noncoding RNA.
Expertise: Biochemistry and molecular genetics
Group Leader and Fellow in Vascular Surgery
Vascular surgery department of the DCV (Département Cœur Vaisseau) of the CHUV (Centre Hospitalier Universitaire Vaudois)
Lab website: http://cvalab.strikingly.com
Research interests: Our goal is to understand the role of endothelial cells and hydrogen sulfide during aging, especially in the context of surgical stress. We are especially interested in optimizing dietary restriction regimen before surgery, to increase hydrogen sulfide and protects from ischemia and reperfusion injuries.
Expertise: Hydrogen Sulfide, Dietary Restriction, Vascular Biology, Transplantation, Surgery.
Ocampo Mendez, Alejandro
University of Lausanne, Pharmacology and Toxicology
Research interests: Our goal is to understand the role of epigenetic dysregulation as driver of aging and disease and develop novel strategies based on epigenetic reprogramming to prevent or revert the manifestation of aging and disease phenotypes.
Lab website: http://bioinfo.unil.ch
Research: Bioinformatics of genome and transcriptome evolution.
Research interests: Molecular evolution, evo-devo, aging, bioinformatics, natural selection, anatomy, genomics.
Lab website: www.altmeyerlab.org
Research interests: Mechanisms of genome integrity maintenance in mammalian cells.
Keywords: DNA Damage Response, Replication Stress, Chromatin Modifications, Quantitative High-Content Microscopy.
Expertise: Cell cycle resolved fluorescence imaging of cellular responses to genotoxic stress, RNAi screens, DNA damage signalling.
Klinik für Geriatrie, Uni Spital Zürich
Chefärztin Universitäre Klinik für Akutgeriatrie
Fachärztin für Allgemeine Innere Medizin inkl. Schwerpunkt Geriatrie
Fachärztin für Physikalische Medizin und Rehabilitation
Lab website: http://ewaldlab.com
Research interests: Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient for extending the lifespan of C. elegans. Our research efforts are focusing on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging.
Expertise: C. elegans ECM, aging, protein aggregation, neurodegeneration (Alzheimer's disease), Insulin/IGF-1 signaling, NADPH oxidases, ROS, oxidative stress, automated lifespan assessment, genetic and chemical high-throughput screening.
Chemistry and Applied Biosciences, ETH Zurich
Lab website: http://www.cabsel.ethz.ch
Research interests: Systems Biology and Bioinformatics.
Keywords: Biology of ageing, Single cell analysis, Cell differentiation.
Expertise: Mathematical modeling, Bioinformatics, Network inference, systems biology, bioinformatics, ageing, network inference, single cell.
Research interests: Research in the Müller group is aimed at multiscale quantification and modelling of bone at the molecular, cellular, and organ level incorporating novel principles and techniques of mechanics, imaging, and in silico modelling applied to the areas of tissue engineering and regeneration, systems mechanobiology and personalized medicine.
Keywords: Bone, aging, tissue engineering and regeneration, systems mechanobiology and personalized medicine.
Expertise: Biomechanics, bioimaging, and in silico modelling.
Lab website: http://www.energymetab.ethz.ch/
Research interests: We are pursuing research on the biochemical and molecular basis of longevity regulation to provide novel therapeutic options to prevent and cure age-related diseases like obesity, diabetes, neurodegeneration and cancer.
Expertise: Reactive Oxygen Species (ROS) within the mitochondria, mitohormesis, RNA expression screen of physiological aging in several evolutionary distinct species, including C. elegans, zebrafish, killifish, and mice.
von Meyenn, Ferdinand
Laboratory of Nutrition and Metabolic Epigenetics, D-HEST, ETHZ
Lab website: www.epigenetics.ethz.ch
Research: We aim to gain insights into the complex relationship between nutrition, metabolism and the epigenome
Research interests: Epigenetic regulation of ageing
Expertise: Epigenetics, DNA methylation, Epigenetic Clock
Swiss or Swiss-trained aging researchers across the world
German Center for Neurodegenerative Diseases (DZNE), Germany
Research: Our current research is based on our previous findings that widespread protein aggregation is a hallmark of normal aging in C. elegans (DOI: 10.1371/journal.pbio.1000450). These results have since been confirmed in other organisms including mammals and demonstrate that protein aggregation is not restricted to a disease context.
This novel marker of aging gives us the unprecedented opportunity to discover unique endogenous mechanisms responsible for promoting a healthy proteome. In particular, we aim to understand how longevity-related pathways deal with protein aggregation. Another main aspect of our research is to characterize the similarities and differences between age-dependent protein aggregation and disease-associated protein aggregation. Most importantly we are exploring how age-dependent protein aggregation is linked to unhealthy aging and neurodegeneration.
Expertise: Protein aggregation and aging
Department of Biology, McGill University
Lab website: http://hekimilab.mcgill.ca/home.html
Research: We are using mutants of Caenorhabditis elegans and mouse mutants to understand aging, because it is a crucial, profound, and poorly understood biological phenomenon and because understanding aging might provide new ways for medical intervention on the aging process. We are particularly focussing on activities that affect mitochondrial function, and on mutants that enhance longevity. We are also interested in the biosynthesis and function of ubiquinone (UQ, Coenzyme Q, CoQ), the redox active lipid enzymatic co-factor and membrane antioxidant. Here too we use mutants in both organisms to unravel the basic biochemical functions of ubiquinone and to develop drugs that can help alleviate the diseases linked to ubiquinone deficiency.
Center for Cancer Research, National Cancer Institute, NIH, USA
Research: My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging (doi: 10.1016/j.cell.2016.05.017 and 10.1016/j.cell.2013.12.028).
Research interests: The Misteli Laboratory explores the cell biology of genomes.
Expertise: Genome architecture, lamins, cancer, aging.
Department of Molecular Medicine & Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
Lab website: http://www.scripps.edu/petrascheck/
Research: Identification of small molecules that extend lifespan and thier underlying mechanisms
Research interests: Aging, drug discovery, age-related disease.
Expertise: Chemical genetics of aging.
Department of Medical Genetics, University of British Columbia (UBC), Vancouver, Canada
Lab website: http://cmmt.ubc.ca/taubert-lab/
Research: We study how transcriptional regulation of metabolism and stress responses contributes to aging and age-related disease.
Keywords: Transcription, stress response, lipid metabolism, nuclear receptors.
University of Michigan Medical School, USA
Lab website: https://truttmann.lab.medicine.umich.edu/
Research: Post-translational protein regulation in the context of aging and aging-associated diseases.
Research interests: The overall goal of our laboratory is to determine the impact of post-translational protein modifications (PTM) on proteostasis in the context of aging and aging-associated diseases. We are particularly interested in a novel PTM, termed AMPylation, that negatively regulates the activity of heat shock protein 70 (Hsp70) family proteins. We employ numerous genetic, biochemical as well as behavioral approaches in conjunction with several model systems (Saccharomyces cerevisiae, Caenorhabditis elegans, mice, primary human tissue) to elucidate how PTMs control chaperone activity and regulate proteostasis.
Expertise: C. elegans, protein aggregation (in vitro and in vivo), neurodegeneration (Alzheimer's disease, Parkinson's disease, polyQ diseases), stress signaling, protein AMPylation, Yeast models, mouse models, histology, fluorescence microscopy, CRISPR/Cas9 (worm, mouse, human cell lines), in-vitro biochemistry, protein purification
Lab website: http://web.stanford.edu/group/twclab/cgi-bin/
Research interests: Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer's disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain (DOI 10.1038/nature20411).