Publications

Natasha Whitehead, Jonathan F. Gill, Marijke Brink, and Christoph Handschin
Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart
Front. Physiol., 21 March 2018 https://doi.org/10.3389/fphys.2018.00242

Gill JF, Santos G, Schnyder S, Handschin C.

PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12697. Epub 2017 Oct 25.

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.

Elife. 2017 Jan 13;6. pii: e19493. doi: 10.7554/eLife.19493.

https://elifesciences.org/articles/19493

González A, Hall MN.

Nutrient sensing and TOR signaling in yeast and mammals.

EMBO J. 2017 Feb 15;36(4):397-408. doi: 10.15252/embj.201696010. Epub 2017 Jan 17. Review.

Garschall K, Dellago H, Gáliková M, Schosserer M, Flatt T, Grillari J.

Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span.

NPJ Aging Mech Dis. 2017 Mar 15;3:5. doi: 10.1038/s41514-017-0005-z. eCollection 2017.

Vancevska A, Douglass KM, Pfeiffer V, Manley S, Lingner J.

The telomeric DNA damage response occurs in the absence of chromatin decompaction.

Vancevska A, Douglass KM, Pfeiffer V, Manley S, Lingner J.

Genes Dev. 2017 Mar 15;31(6):567-577. doi: 10.1101/gad.294082.116. Epub 2017 Apr 5.

Sobel JA, Krier I, Andersin T, Raghav S, Canella D, Gilardi F, Kalantzi AS, Rey G, Weger B, Gachon F, Dal Peraro M, Hernandez N, Schibler U, Deplancke B, Naef F; CycliX consortium.

Transcriptional regulatory logic of the diurnal cycle in the mouse liver.

PLoS Biol. 2017 Apr 17;15(4):e2001069. doi: 10.1371/journal.pbio.2001069. eCollection 2017 Apr.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Aging Cell. 2017 May 22. doi: 10.1111/acel.12610. [Epub ahead of print] PMID: 28544360

Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M.

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin.

Cell Rep. 2017 May 30;19(9):1819-1831. doi: 10.1016/j.celrep.2017.05.016.

Reinhard JR, Lin S, McKee KK, Meinen S, Crosson SC, Sury M, Hobbs S, Maier G, Yurchenco PD, Rüegg MA.

Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal4649. doi: 10.1126/scitranslmed.aal4649.

Martino MM, Maruyama K, Kuhn GA, Satoh T, Takeuchi O, Müller R, Akira S.

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nat Commun. 2016 Mar 22;7:11051. doi: 10.1038/ncomms11051.

Guridi M, Kupr B, Romanino K, Lin S, Falcetta D, Tintignac L, Rüegg MA.

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.

Skelet Muscle. 2016 Mar 21;6:13. doi: 10.1186/s13395-016-0084-8. eCollection 2016.

Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J.

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28.

Williams EG, Wu Y, Jha P, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R, Auwerx J.

Systems proteomics of liver mitochondria function.

Science. 2016 Jun 10;352(6291):aad0189. doi: 10.1126/science.aad0189.

Deplancke B, Alpern D, Gardeux V.

The Genetics of Transcription Factor DNA Binding Variation.

Cell. 2016 Jul 28;166(3):538-54. doi: 10.1016/j.cell.2016.07.012. Review.

Rodrigues MA, Flatt T.

Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects.

Curr Opin Insect Sci. 2016 Aug;16:1-8. doi: 10.1016/j.cois.2016.04.013. Epub 2016 Apr 29. Review.

Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J.

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.

Lukjanenko L, Jung MJ, Hegde N, Perruisseau-Carrier C, Migliavacca E, Rozo M, Karaz S, Jacot G, Schmidt M, Li L, Metairon S, Raymond F, Lee U, Sizzano F, Wilson DH, Dumont NA, Palini A, Fässler R, Steiner P, Descombes P, Rudnicki MA, Fan CM, von Maltzahn J, Feige JN, Bentzinger CF.

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.

Nat Med. 2016 Aug;22(8):897-905. doi: 10.1038/nm.4126. Epub 2016 Jul 4. PMID:27376579

http://www.nature.com/nm/journal/v22/n8/full/nm.4126.html

Hall MN

TOR and paradigm change: cell growth is controlled.

Mol Biol Cell. 2016 Sep 15;27(18):2804-6. doi: 10.1091/mbc.E15-05-0311. Review.

Vetsch JR, Müller R, Hofmann S.

The influence of curvature on three-dimensional mineralized matrix formation under static and perfused conditions: an in vitro bioreactor model.

J R Soc Interface. 2016 Oct;13(123). pii: 20160425.

Aeby E, Ahmed W, Redon S, Simanis V, Lingner J.

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase.

Cell Rep. 2016 Dec 20;17(12):3107-3114. doi: 10.1016/j.celrep.2016.11.071

Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN.

Syrosingopine sensitizes cancer cells to killing by metformin.

Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec.

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15. PMID: 25517099
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/

Lambers FM, Kuhn G, Weigt C, Koch KM, Schulte FA, Müller R.

Bone adaptation to cyclic loading in murine caudal vertebrae is maintained with age and directly correlated to the local micromechanical environment.

J Biomech. 2015 Apr 13;48(6):1179-87. doi: 10.1016/j.jbiomech.2014.11.020. Epub 2014 Dec 8.

Lakshmanan LN, Gruber J, Halliwell B, Gunawan R.

Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

Nucleic Acids Res. 2015 Apr 30;43(8):4098-108. doi: 10.1093/nar/gkv299. Epub 2015 Apr 8.

Tam ZY, Gruber J, Halliwell B, Gunawan R

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations.

PLoS Comput Biol. 2015 May 21;11(5):e1004183. doi: 10.1371/journal.pcbi.1004183. eCollection 2015 May.

Altmeyer M, Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grøfte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J.

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

Nat Commun. 2015 Aug 19;6:8088. doi: 10.1038/ncomms9088.

Waszak SM, Delaneau O, Gschwind AR, Kilpinen H, Raghav SK, Witwicki RM, Orioli A, Wiederkehr M, Panousis NI, Yurovsky A, Romano-Palumbo L, Planchon A, Bielser D, Padioleau I, Udin G, Thurnheer S, Hacker D, Hernandez N, Reymond A, Deplancke B, Dermitzakis ET.

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.

Cell. 2015 Aug 27;162(5):1039-50. doi: 10.1016/j.cell.2015.08.001. Epub 2015 Aug 20.

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte O, Zarse K, Ristow M 

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.

Nature Commun 6:10043 (2015)

http://www.nature.com/articles/ncomms10043

Guridi M, Tintignac LA, Lin S, Kupr B, Castets P, Rüegg MA.

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Sci Signal. 2015 Nov 10;8(402):ra113. doi: 10.1126/scisignal.aab3715.

Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB 3rd, Salomon DR, Petrascheck M.

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.

Elife. 2015 Dec 1;4:e08833. doi: 10.7554/eLife.08833

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